Dengshun Miao

 

CURRICULUM VITAE
 
Dengshun Miao
 
1.      Personal Information
 
Title/Position: Distinguished Professor, Dept. of Human Anatomy,
Director of the Research Center for Bone and Stem Cells
 
Correspondence Address: The Research Center for Bone and Stem Cells,
Nanjing Medical University
                                       Xian Zhi Building, Room 602
140# Han Zhong road, Nanjing, Jiangsu, China 210029
 
Telephone: 011-86-25-8686-2015
 
Fax: 011-86-25-8686-2015
 
E-mail: dsmiao@njmu.edu.cn
 
2. Education
INSTITUTION AND LOCATION
DEGREE
(if applicable)
MM/YY
FIELD OF STUDY
Nanjing Medical University
M.S.
07/87
Human Anatomy
University of Edinburgh
Postdoctoral
12/95
Dept of Surgery
University of Sheffield Medical School
Ph.D.
01/99
Human Metabolism
McGill University
Postdoctoral
06/02
Dept of Medicine
 
 
 
 
 
3. Research Interests
I am currently conducting research in two areas: (1) Aging and related disease; (2) Actions of calcium-regulating hormones including parathyroid hormone, parathyroid hormone related peptide and active vitamin D on skeletal and extra skeletal health.
 
4. Selected Publications
5.        Liu, J., Lv, F., Sun, W., Tao, C., Ding, G., Karaplis, A., Brown, E., Goltzman, D., and Miao, D. (Corresponding Author) 2011. The Abnormal Phenotypes of Cartilage and Bone in Neonatal Calcium-Sensing Receptor Deficient Mice Are Dependent on the Actions of Calcium, Phosphorus and PTH. PLoS Genetics. 7(9): e1002294.
6.        Zhang, D., Li, Y., Zhu, T., Zhang, F., Yang, Z., and Miao, D. (Corresponding Author) 2011. Zinc supplementation results in improved therapeutic potential of bone marrow-derived mesenchymal stromal cells in a mouse ischemic limb model. Cytotherapy 13:156-164.
7.        Zhang, D., Jiang, M., and Miao, D. (Corresponding Author) 2011. Transplanted human amniotic membrane-derived mesenchymal stem cells ameliorate carbon tetrachloride-induced liver cirrhosis in mouse. PLoS One 6:e16789.
8.        Shu, L., Ji, J., Zhu, Q., Cao, G., Karaplis, A., Pollak, M.R., Brown, E., Goltzman, D., and Miao, D. (Corresponding Author) 2011. The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates. J Bone Miner Res 26:1057-1071.
9.        Ren, Y., Liu, B., Feng, Y., Shu, L., Cao, X., Karaplis, A., Goltzman, D., and Miao, D. (Corresponding Author) 2011. Endogenous PTH Deficiency Impairs Fracture Healing and Impedes the Fracture-Healing Efficacy of Exogenous PTH(1-34). PLoS One.
10.    Jin, J., Zhao, Y., Tan, X., Guo, C., Yang, Z., and Miao, D. (Corresponding Author) 2011. An improved transplantation strategy for mouse mesenchymal stem cells in an acute myocardial infarction model. PLoS One 6:e21005.
11.    Ji, J., Lu, R., Zhou, X., Xue, Y., Shi, C., Goltzman, D., and Miao, D. (Corresponding Author) 2011. 1,25-dihydroxyvitamin D3 Contributes to Regulating Mammary Calcium Transport and Modulates Neonatal Skeletal Growth and Turnover Cooperatively with Calcium. Am J Physiol Endocrinol Metab.
12.    Dai, Z., Chung, S.K., Miao, D., Lau, K.S., Chan, A.W., and Kung, A.W. 2011. Sodium/myo-inositol cotransporter 1 and myo-inositol are essential for osteogenesis and bone formation. J Bone Miner Res.
13.    Chen, L., Liu, H., Sun, W., Bai, X., Karaplis, A.C., Goltzman, D., and Miao, D. (Corresponding Author) 2011. Fibroblast growth factor 23 overexpression impacts negatively on dentin mineralization and dentinogenesis in mice. Clin Exp Pharmacol Physiol 38:395-402.
14.    Zhang, H.W., Ding, J., Jin, J.L., Guo, J., Liu, J.N., Karaplis, A., Goltzman, D., and Miao, D. (Corresponding Author) 2010. Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res 25:640-652.
15.    Sun, W., Xie, H., Ji, J., Zhou, X., Goltzman, D., and Miao, D. (Corresponding Author) 2010. Defective female reproductive function in 1,25(OH)2D-deficient mice results from indirect effect mediated by extracellular calcium and/or phosphorus. Am J Physiol Endocrinol Metab 299:E928-935.
16.    Sun, W., Liu, J., Zhou, X., Xiao, Y., Karaplis, A., Pollak, M.R., Brown, E., Goltzman, D., and Miao, D. (Corresponding Author) 2010. Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice. Development 137:985-992.
17.    Liu, P., Bai, X., Wang, H., Karaplis, A., Goltzman, D., and Miao, D. (Corresponding Author). 2009. Hypophosphatemia-mediated hypotension in transgenic mice overexpressing human FGF-23. Am J Physiol Heart Circ Physiol 297:H1514-1520.
18.    Liu, H., Guo, J., Wang, L., Chen, N., Karaplis, A., Goltzman, D., and Miao, D. (Corresponding Author). 2009. Distinctive anabolic roles of 1,25-dihydroxyvitamin D(3) and parathyroid hormone in teeth and mandible versus long bones. J Endocrinol 203:203-213.
19.    Cao, G., Gu, Z., Ren, Y., Shu, L., Tao, C., Karaplis, A., Goltzman, D., and Miao, D. (Corresponding Author). 2009. Parathyroid hormone contributes to regulating milk calcium content and modulates neonatal bone formation cooperatively with calcium. Endocrinology 150:561-569.
20.    Zhang, Z.L., Tong, J., Lu, R.N., Scutt, A.M., Goltzman, D., and Miao, D. (Corresponding Author). 2009. Therapeutic potential of non-adherent BM-derived mesenchymal stem cells in tissue regeneration. Bone Marrow Transplant 43:69-81.
21.    Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., and Miao, D. (Corresponding Author). 2008. Calcium-independent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int 74:170-179.
22.    Miao, D., Su, H., He, B., Gao, J., Xia, Q., Zhu, M., Gu, Z., Goltzman, D., and Karaplis, A.C. 2008. Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein. Proc Natl Acad Sci U S A 105:20309-20314.
23.    Xue, Y., Karaplis, A.C., Hendy, G.N., Goltzman, D., and Miao, D. (Corresponding Author). 2006. Exogenous 1,25-dihydroxyvitamin D3 exerts a skeletal anabolic effect and improves mineral ion homeostasis in mice that are homozygous for both the 1alpha-hydroxylase and parathyroid hormone null alleles. Endocrinology 147:4801-4810.
24.    Xue, Y., Zhang, Z., Karaplis, A.C., Hendy, G.N., Goltzman, D., and Miao, D. (Corresponding Author). 2005. Exogenous PTH-related protein and PTH improve mineral and skeletal status in 25-hydroxyvitamin D-1alpha-hydroxylase and PTH double knockout mice. J Bone Miner Res 20:1766-1777.
25.    Xue, Y., Karaplis, A.C., Hendy, G.N., Goltzman, D., and Miao, D. (Corresponding Author). 2005. Genetic models show that parathyroid hormone and 1,25-dihydroxyvitamin D3 play distinct and synergistic roles in postnatal mineral ion homeostasis and skeletal development. Hum Mol Genet 14:1515-1528.
26.    Miao, D., He, B., Jiang, Y., Kobayashi, T., Soroceanu, M.A., Zhao, J., Su, H., Tong, X., Amizuka, N., Gupta, A., et al. 2005. Osteoblast-derived PTHrP is a potent endogenous bone anabolic agent that modifies the therapeutic efficacy of administered PTH 1-34. J Clin Invest 115:2402-2411.
27.    Panda, D.K., Miao, D. (Co-first author), Bolivar, I., Li, J., Huo, R., Hendy, G.N., and Goltzman, D. 2004. Inactivation of the 25-hydroxyvitamin D 1alpha-hydroxylase and vitamin D receptor demonstrates independent and interdependent effects of calcium and vitamin D on skeletal and mineral homeostasis. J Biol Chem 279:16754-16766.
28.    Miao, D., Murant, S., Scutt, N., Genever, P., and Scutt, A. 2004. Megakaryocyte-bone marrow stromal cell aggregates demonstrate increased colony formation and alkaline phosphatase expression in vitro. Tissue Eng 10:807-817.
29.    Miao, D., Liu, H., Plut, P., Niu, M., Huo, R., Goltzman, D., and Henderson, J.E. 2004. Impaired endochondral bone development and osteopenia in Gli2-deficient mice. Exp Cell Res 294:210-222.
30.    Miao, D., Li, J., Xue, Y., Su, H., Karaplis, A.C., and Goltzman, D. 2004. Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice. Endocrinology 145:3554-3562.
31.    Miao, D., He, B., Lanske, B., Bai, X.Y., Tong, X.K., Hendy, G.N., Goltzman, D., and Karaplis, A.C. 2004. Skeletal abnormalities in Pth-null mice are influenced by dietary calcium. Endocrinology 145:2046-2053.
32.    Miao, D., Bai, X., Panda, D.K., Karaplis, A.C., Goltzman, D., and McKee, M.D. 2004. Cartilage abnormalities are associated with abnormal Phex expression and with altered matrix protein and MMP-9 localization in Hyp mice. Bone 34:638-647.
33.    Miao, D., and Scutt, A. 2002. Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage. J Histochem Cytochem 50:333-340.
34.    Miao, D., and Scutt, A. 2002. Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo. BMC Musculoskelet Disord 3:16.
35.    Miao, D., He, B., Karaplis, A.C., and Goltzman, D. 2002. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 109:1173-1182.
36.    Bai, X., Miao, D. (Co-first author), Panda, D., Grady, S., McKee, M.D., Goltzman, D., and Karaplis, A.C. 2002. Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol 16:2913-2925.
37.    Panda, D.K., Miao, D. (Co-first author), Tremblay, M.L., Sirois, J., Farookhi, R., Hendy, G.N., and Goltzman, D. 2001. Targeted ablation of the 25-hydroxyvitamin D 1alpha -hydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. Proc Natl Acad Sci U S A 98:7498-7503.
38.    Miao, D., Tong, X.K., Chan, G.K., Panda, D., McPherson, P.S., and Goltzman, D. 2001. Parathyroid hormone-related peptide stimulates osteogenic cell proliferation through protein kinase C activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 276:32204-32213.
39.    Miao, D., Bai, X., Panda, D., McKee, M., Karaplis, A., and Goltzman, D. 2001. Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition. Endocrinology 142:926-939.
40.    Miao, D., Skibinski, G., and James, K. 1996. The effects of human seminal plasma and PGE2 on mitogen induced proliferation and cytokine production of human splenic lymphocytes and peripheral blood mononuclear cells. J Reprod Immunol 30:97-114.
41.     Miao, D., He, B., Lanske, B., Bai, XY., Tong, XK., Hendy, GN., Goltzman, D. and Karaplis, AC. 2005:. Skeletal and reproductive abnormalities in pth-null mice. In: Molecular Biology of the Parathyroid. Naveh-Many, Tally (Ed.). 179-197.
 
5. Scholarly and Professional Activities
Member       Chinese Society of Human Anatomy
Member       American Society of Bone and Mineral Research
Member       The Endocrine Society
Member       American Society of Physiology
Vice President Jiangsu Society of Osteoporosis and Bone Mineral Research
Director of Academic committee     Jiangsu Society of Experimental Animals

Adjunct Professor, Dept of Medicine, McGill University, Canada